Research Groups

At the CSC we use modern biological approaches and patient-derived information to gain an understanding of the molecular and physiological basis of health and disease. CSC research programmes are focused in three Sections: Epigenetics, Brain Repair and Dysfunction, and Genes and Metabolism. Strengths in these areas provide unique opportunities for scientific discovery and healthcare benefit. Indeed, our research is now widely recognised through national and international awards. Strategic partnerships with Imperial College, the AHSC and with industry facilitate translation of our research. Strategic partnerships with Imperial College, the AHSC and with industry facilitate translation of our research.

• Epigenetics

  

  The section studies epigenetically regulated processes in the cell, with an emphasis on stem cell development and its consequences on gene regulation, DNA replication and chromosome organisation. Another focus area is the relationship between epigenetic regulation and important processes such as gene expression, cell cycle control and the development of cancer. To analyse these processes we rely on cell biological, biochemical, genomic and in vivo methods.

  *CSC Associate Groups

• Brain Repair and Dysfunction

  

  Research in this section focuses on understanding neural development and plasticity, the nature of neurological and psychiatric disorders, and improving diagnoses and treatments. Experimental methods include cell and molecular approaches and in vivo imaging, particularly PET and MRI.

• Genes and Metabolism

  

  This section aims to understand the molecular and cellular basis of a variety of metabolic and cardiovascular disorders and apply this understanding to improved healthcare. The groups use a combination of approaches, including biochemical, genomic, physiological and imaging techniques.