Research Groups > Lymphocyte Development
“We use lymphocytes as models to study how gene expression patterns are transmitted through cell division, and to explore the molecular basis of lineage choice”
We study transcriptional and epigenetic mechanisms that underlie cellular differentiation and experimental reprogramming. Our core research activities include the following interrelated areas:
- Pluripotency and reprogramming
- REST and Polycomb repressor complexes in stem cells
- Cohesin function in gene expression and genome organisation
- Ikaros family transcription factors
We combine classical cell biology and genetics approaches with current technologies to address the events involved in maintaining embryonic stem (ES) cell pluripotency versus differentiation towards mesoderm, endoderm and ectoderm, as well as the mechanisms of T and B cell lineage choice and differentiation.
DNA synthesis (green) in B cells undergoing pluripotent reprogramming. Click to enlarge.
Group heads
Amanda Fisher (Professor)
Telephone 38249 (Director) 38238/38242 (Group)
Email
Matthias Merkenschlager (Professor)
Telephone 38239
Email
Group members
Hakan Bagci (Mr)
Telephone 32145
Email
Karen Brown (Dr)
Telephone 38286
Email
Ludovica Bruno (Dr)
Telephone 32145
Email
Lesly Calderon Dominguez (Dr)
Telephone 38286
Email
Irene Cantone (Miss)
Telephone 38286
Email
Lee Cooper (Mr)
Telephone 32145
Email
Isabel Ferreiros Vidal (Dr)
Telephone 38286
Email
Amelie Feytout (Dr)
Telephone x38236
Email
Preksha Gupta (Miss)
Telephone 32145
Email
David Landeira (Dr)
Telephone 38286
Email
Thais Lavagnolli (Ms)
Telephone 32145
Email
Feng Li (Dr)
Telephone 38286
Email
Ziwei Liang (Miss)
Telephone 32145
Email
Andy Malinowski (Mr)
Telephone 32145
Email
Allifia Abbas Newsholme (Dr)
Telephone 32145
Email
Francesco Piccolo (Mr)
Telephone 32145
Email
Jorge Soza Ried (Mr)
Telephone 38286
Email
Vlad Seitan (Dr)
Telephone 38286
Email
Matthew Van de Pette (Dr)
Telephone 38286
Email
Admin contact
Tathiana Santana (Ms)
Telephone 38236
Email
Contact details
Telephone: +44 (0) 20 8383 8238/8239
Facsimile: +44 (0) 20 8383 8338
Facsimile: +44 (0) 20 8383 8338
Selected publications
Tsubouchi, T., Soza-Ried, J., Brown, K., Piccolo, F. M., Cantone, I., Landeira, D., Bagci, H., Hochegger, H., Merkenschlager, M., Fisher, A. G. (2013). DNA synthesis is required for reprogramming mediated by stem cell fusion. Cell, In press
Seitan VC, Hao B, Tachibana-Konwalski K, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, Terry A, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG, Krangel MS, Nasmyth K, Merkenschlager M, (2011) A role for cohesin in t-cell-receptor rearrangement and thymocyte differentiation. Nature 476, 467–471. Abstract
Jørgensen, H. F. and Fisher, A. G. (2010). Can Controversies be put to REST? Nature 467, E3–E4. Abstract
Pereira, C. F., Piccolo, F. M., Tsubouchi, T., Sauer, S., Ryan, N. K., Bruno, L., Landeira, D., Santos, J., Banito, A., Gil, J. Koseki, H., Merkenschlager, M. and Fisher, A. G. (2010). ESCs require Prc2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell 6, 547–556. Abstract
Landeira, D., Sauer, S., Poot, R., Dvorkina, M., Mazzarella, L., Jørgensen, H. F., Pereira, C. F., Leleu, M., Piccolo, F. M., Spivakov, M., Brookes, E., Pombo, A., Fisher, C., Skarnes, W. C., Snoek, T., Bezstarosti, K., Demmers, J., Klose, R. J., Casanova, M., Tavares, L., Brockdorff, N., Merkenschlager, M., Fisher, A. G. (2010). Jarid2 is a Prc2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of Prc1 and RNA polymerase II to developmental regulators. Nature Cell Biology 12, 618–624. Abstract
Hadjur, S, Williams, L. M., Ryan, N. K., Cobb, B. S., Sexton, T., Fraser, P., Fisher, A. G., Merkenschlager, M. (2009). Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature 460, 410–413. Abstract
Parelho, V., Hadjur, S., Spivakov, M., Leleu, M., Sauer, S., Gregson, H. C., Jarmuz, A., Canzonetta, C., Webster, Z., Nesterova, T., Cobb, B. S., Yokomori, K., Dillon, N., Aragon, L., Fisher, A. G. & Merkenschlager, M. (2008). Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell 132, 422-433. Abstract
Seitan VC, Hao B, Tachibana-Konwalski K, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, Terry A, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG, Krangel MS, Nasmyth K, Merkenschlager M, (2011) A role for cohesin in t-cell-receptor rearrangement and thymocyte differentiation. Nature 476, 467–471. Abstract
Jørgensen, H. F. and Fisher, A. G. (2010). Can Controversies be put to REST? Nature 467, E3–E4. Abstract
Pereira, C. F., Piccolo, F. M., Tsubouchi, T., Sauer, S., Ryan, N. K., Bruno, L., Landeira, D., Santos, J., Banito, A., Gil, J. Koseki, H., Merkenschlager, M. and Fisher, A. G. (2010). ESCs require Prc2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell 6, 547–556. Abstract
Landeira, D., Sauer, S., Poot, R., Dvorkina, M., Mazzarella, L., Jørgensen, H. F., Pereira, C. F., Leleu, M., Piccolo, F. M., Spivakov, M., Brookes, E., Pombo, A., Fisher, C., Skarnes, W. C., Snoek, T., Bezstarosti, K., Demmers, J., Klose, R. J., Casanova, M., Tavares, L., Brockdorff, N., Merkenschlager, M., Fisher, A. G. (2010). Jarid2 is a Prc2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of Prc1 and RNA polymerase II to developmental regulators. Nature Cell Biology 12, 618–624. Abstract
Hadjur, S, Williams, L. M., Ryan, N. K., Cobb, B. S., Sexton, T., Fraser, P., Fisher, A. G., Merkenschlager, M. (2009). Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature 460, 410–413. Abstract
Parelho, V., Hadjur, S., Spivakov, M., Leleu, M., Sauer, S., Gregson, H. C., Jarmuz, A., Canzonetta, C., Webster, Z., Nesterova, T., Cobb, B. S., Yokomori, K., Dillon, N., Aragon, L., Fisher, A. G. & Merkenschlager, M. (2008). Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell 132, 422-433. Abstract
