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Positron Emission Tomography (PET) at the Biological Imaging Centre > Radiotracers and Radioligands

Examples of radiotracers and radioligands that can be used to study genetics, biochemistry,
physiology and pharmacology in rodent models

Radiotracer/radioligand
Process measured
Used at BIC?
Multi-purpose    
[18F]fluorodeoxyglucose Glucose transport and hexokinase activity in brain, myocardium, tumours and infection. Yes
[124I]NaI Sodium iodide symporter substrate for imaging gene expression Yes
[18F]fluoro-3-hydroxy-methylguanine HSV1-tk/HSV1-r39tk substrate for imaging gene expression  
[15O]H2O Blood flow in brain, myocardium, tumours and most normal tissues.  
[15O]CO Blood volume in brain, myocardium and tumours  
[11C]daunorubicin Multi-drug resistance phenotype in brain and tumours  
     
Oncology    
[18F]fluorothymidine Thymidine kinase 1 activity and cell proliferation Yes
[11C]methionine Protein synthesis  
[18F]fluoroetanidazole Hypoxia Yes
[124I]annexin V Apoptosis Yes
[124I]VG76e Vascular endothelial growth factor status Yes
[11C]choline Choline kinase activity and Ras-Erk signalling Yes
5-[18F]fluorouracil 5-Fluorouracil tissue pharmacokinetics Yes
     
Neurosciences    
[11C]raclopride Dopamine D2/3 receptor density Yes
[18F]fluorodopa Pre-synaptic dopamine neuron density; useful as nigrostriatal dopamine marker Yes
[11C]WAY100635 5HT1A1 receptor density Yes
[11C]MDL100907 5HT2A receptor density Yes
[11C]diprenorphine Opioid receptor (non-subtype selective) density  
[11C]flumazenil Benzodiazepine binding site  
(R)-[11C]PK11195 Microglial acitivation  
[11C]DASB Serotonin transport Yes
[11C]PIB ß-amyloid plaques (Alzheimer phenotype)  
     
Cardiology    
[11C]GB67G α1-adrenoceptor status  
(S)-[11C]CGP-12177 ß-adrenoceptor status  
[11C]methyl quinuclidinyl benzylate Cardiac muscarinic receptor status  
[11C]meta-hydroxyephedrine Pre-synaptic catecholamine reuptake status  
     
Rheumatology    
[18F]F- Bone turnover Yes

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