Latest publications from Lymphocyte Development Research Group

Tue, 17 Apr 2012

2012-04-17 09:57:51 GMT

Seitan, V. C., Krangel, M. S., Merkenschlager, M., (2012). Cohesin, CTCF and lymphocyte antigen receptor locus rearrangement. Trends in immunology 33, 153-159 Abstract

Mon, 6 Feb 2012

2012-02-06 12:22:05 GMT

Seitan, V. C., Merkenschlager, M. (2011). Cohesin and chromatin organisation. Current Opinion in Genetics & Development, in press Abstract

Mon, 6 Feb 2012

2012-02-06 12:19:59 GMT

Clemente-Blanco, A., Sen, N., Mayan-Santos, M., Sacristán, M. P., Graham, B., Jarmuz, A., Giess, A., Webb, E., Game, L., Eick, D., Bueno, A., Merkenschlager, M., Aragón, L. (2011). Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription. Nature Cell Biology, in press. Abstract

Tue, 13 Sep 2011

2011-09-13 15:55:56 GMT

Seitan VC, Hao B, Tachibana-Konwalski K, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, Terry A, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG, Krangel MS, Nasmyth K, Merkenschlager M, (2011) A role for cohesin in t-cell-receptor rearrangement and thymocyte differentiation. Nature 476, 467–471. Abstract

Thu, 1 Sep 2011

2011-09-01 10:10:34 GMT

Cobb, B. S., Hertweck, A., Smith, J., O'Connor, E., Graf, D., Cook, T., Smale, S. T., Sakaguchi, S., Livesey, F. J., Fisher, A. G., & Merkenschlager, M. (2006). A role for Dicer in immune regulation. The Journal of Experimental Medicine 203, 2519-2527. Abstract

Thu, 1 Sep 2011

2011-09-01 10:09:50 GMT

Jørgensen, H. F., Chen, Z.-F., Merkenschlager, M., Fisher, A. G., (2009). Is REST required for ES cell pluripotency? Nature 457, E4–E5. Abstract

Mon, 11 Jul 2011

2011-07-11 14:11:09 GMT

Piccolo, F. M., Pereira, C. F., Cantone, I., Brown, K., Tsubouchi, T., Soza-Ried, J., Merkenschlager, M., Fisher, A. G.(2011). Using heterokaryons to understand pluripotency and reprogramming. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 366, 2260–2265. Abstract

Wed, 29 Jun 2011

2011-06-29 13:58:13 GMT

Cantone, I., Fisher, A. G. (2011). Unraveling epigenetic landscapes: the enigma of enhancers. Cell Stem Cell 8, 128–129. Abstract

Mon, 21 Feb 2011

2011-02-21 14:11:54 GMT

Fisher, C. L., Fisher, A. G. (2011). Chromatin states in pluripotent, differentiated, and reprogrammed cells. Current Opinion in Genetics & Development, in press. Abstract

Mon, 14 Feb 2011

2011-02-14 15:32:58 GMT

Landeira, D., Fisher, A. G. (2010). Inactive yet indispensable: the tale of Jarid2. Trends in Cell Biology 21, 74–80. Abstract

Mon, 14 Feb 2011

2011-02-14 15:32:49 GMT

Mazzarella, L., Jørgensen, H. F., Soza-Ried, J., Terry, A. V., Pearson, S., Lacaud, G., Kouskoff, V., Merkenschlager, M., Fisher, A. G. (2010). ES cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression. Blood 117, 83–87. Abstract

Mon, 29 Nov 2010

2010-11-29 13:11:36 GMT

Merkenschlager, M. (2010). Ikaros in immune receptor signaling, lymphocyte differentiation, and function. FEBS Letters, in press. Abstract

Mon, 29 Nov 2010

2010-11-29 13:08:12 GMT

Merkenschlager, M. (2010). Cohesin: a global player in chromosome biology with local ties to gene regulation. Current Opinion in Genetics, in press. Abstract

Mon, 29 Nov 2010

2010-11-29 13:05:42 GMT

Konopka, W., Kiryk, A., Novak, M., Herwerth, M., Parkitna, J. R. R., Wawrzyniak, M., Kowarsch, A., Michaluk, P., Dzwonek, J., Arnsperger, T., Wilczynski, G., Merkenschlager, M., Theis, F. J., Köhr, G., Kaczmarek, L., Schütz, G. (2010). MicroRNA loss enhances learning and memory in mice. The Journal of Neuroscience 30, 14835–14842. Abstract

Fri, 3 Sep 2010

2010-09-03 17:29:35 GMT

Jørgensen, H. F. and Fisher, A. G. (2010). Can Controversies be put to REST? Nature 467, E3–E4. Abstract

Fri, 27 Aug 2010

2010-08-27 14:39:08 GMT

Schnetz, M. P., Handoko, L., Akhtar-Zaidi, B., Bartels, C. F., Pereira, C. F., Fisher, A. G., Adams, D. J., Flicek, P., Crawford, G. E., Laframboise, T., Tesar, P., Wei, C.-L. L., Scacheri, P. C. (2010). CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genetics 6, e1001023. Abstract

Fri, 27 Aug 2010

2010-08-27 14:37:24 GMT

Fisher, A. G., Merkenschlager, M. (2010). Fresh powder on waddington's slopes. EMBO Reports 11, 490–492. Abstract

Tue, 24 Aug 2010

2010-08-24 16:36:55 GMT

Guo, S., Lu, J., Schlanger, R., Zhang, H., Wang, J. Y., Fox, M. C., Purton, L. E., Fleming, H. H., Cobb, B., Merkenschlager, M., Golub, T. R., Scadden, D. T. (2010). MicroRNA miR-125a controls hematopoietic stem cell number. Proceedings of the National Academy of Sciences of the United States of America 107, 14229–14234. Abstract

Tue, 24 Aug 2010

2010-08-24 16:33:07 GMT

Merkenschlager, M., von Boehmer, H. (2010). PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. The Journal of Experimental Medicine 207, 1347-1350. Abstract

Tue, 24 Aug 2010

2010-08-24 15:55:13 GMT

Zhao, J., Lee, M.-C. C., Momin, A., Cendan, C.-M. M., Shepherd, S. T., Baker, M. D., Asante, C., Bee, L., Bethry, A., Perkins, J. R., Nassar, M. A., Abrahamsen, B., Dickenson, A., Cobb, B. S., Merkenschlager, M., Wood, J. N. (2010). Small rnas control sodium channel expression, nociceptor excitability, and pain thresholds. The Journal of Neuroscience 30, 10860–10871. Abstract

Tue, 24 Aug 2010

2010-08-24 15:08:38 GMT

Liber, D., Domaschenz, R., Holmqvist, P.-H. H., Mazzarella, L., Georgiou, A., Leleu, M., Fisher, A. G., Labosky, P. A., Dillon, N. (2010). Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage. Cell Stem Cell 7, 114–126. Abstract

Tue, 24 Aug 2010

2010-08-24 13:41:57 GMT

Spruce, T., Pernaute, B., Di-Gregorio, A., Cobb, B. S., Merkenschlager, M., Manzanares, M., Rodriguez, T. A. (2010). An early developmental role for mirnas in the maintenance of extraembryonic stem cells in the mouse embryo. Developmental Cell 19, 207–219. Abstract

Wed, 14 Jul 2010

2010-07-14 11:29:27 GMT

Pereira, C. F., Piccolo, F. M., Tsubouchi, T., Sauer, S., Ryan, N. K., Bruno, L., Landeira, D., Santos, J., Banito, A., Gil, J. Koseki, H., Merkenschlager, M. and Fisher, A. G. (2010). ESCs require Prc2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell 6, 547–556. Abstract

Tue, 15 Jun 2010

2010-06-15 09:48:34 GMT

Kanhere, A., Viiri, K., Araújo, C. C., Rasaiyaah, J., Bouwman, R. D., Whyte, W. A., Pereira, C. F., Brookes, E., Walker, K., Bell, G. W., Pombo, A., Fisher, A. G., Young, R. A. and Jenner, R. G. (2010). Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2. Molecular Cell 38, 675–688. Abstract

Mon, 14 Jun 2010

2010-06-14 14:44:01 GMT

Jørgensen, H. F., Terry, A., Beretta, C., Pereira, C. F., Leleu, M., Chen, Z. F., Kelly, C., Merkenschlager, M. and Fisher, A. G. (2009). Rest selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development 136 (5), 715–721. Abstract

Mon, 14 Jun 2010

2010-06-14 14:35:44 GMT

Hoogenkamp, M., Lichtinger, M., Krysinska, H., Lancrin, C., Clarke, D., Williamson, A., Mazzarella, L., Ingram, R., Jorgensen, H., Fisher, A., Tenen, D. G., Kouskoff, V., Lacaud, G. and Bonifer, C. (2009). Early chromatin unfolding by RUNX1 - a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program. Blood 114, 299–309. Abstract

Mon, 14 Jun 2010

2010-06-14 14:34:41 GMT

Fedeli, M., Napolitano, A., Wong, M. P. M. P., Marcais, A., de Lalla, C., Colucci, F., Merkenschlager, M., Dellabona, P., Casorati, G. (2009). Dicer-dependent microrna pathway controls invariant nkt cell development. Journal of Immunology 183, 2506-2512. Abstract

Mon, 14 Jun 2010

2010-06-14 14:33:41 GMT

Bruno, L. and Merkenschlager, M. (2008). Directing T cell differentiation and function with small molecule inhibitors. Cell Cycle 7, 2296–2298. Abstract

Mon, 14 Jun 2010

2010-06-14 14:31:58 GMT

Hadjur, S., Bruno, L., Hertweck, A., Cobb, B. S., Taylor, B., Fisher, A. G. and Merkenschlager, M. (2009). IL4 blockade of inducible regulatory T cell differentiation: The role of Th2 cells, Gata3 and PU.1. Immunology Letters. 122, 37–43. Abstract

Mon, 14 Jun 2010

2010-06-14 14:29:42 GMT

Taylor, B., Cobb, B. S., Bruno, L., Webster, Z., Fisher, A. G. and Merkenschlager, M. (2009). A reappraisal of evidence for probabilistic models of allelic exclusion. PNAS, 106, 516–521. Abstract

Mon, 14 Jun 2010

2010-06-14 14:28:06 GMT

Jørgensen, H. F. and A. G. Fisher (2009). Locking in cellular potential. Cell Stem Cell 4, 192–194. Abstract

Mon, 14 Jun 2010

2010-06-14 14:27:34 GMT

Caparros, M.-L. L., Fisher, A. G. G. & Merkenschlager, M. (2009). Chromosomes and expression mechanisms: life on the edge. Current Opinion in Genetics & Development 19, 97–98. Abstract

Mon, 14 Jun 2010

2010-06-14 14:22:39 GMT

Pereira, C. F. and Fisher, A. G. (2009). Heterokaryon-based reprogramming for pluripotency. Current Protocols in Stem Cell Biology, Chapter 4. Abstract

Mon, 14 Jun 2010

2010-06-14 14:20:52 GMT

Hadjur, S, Williams, L. M., Ryan, N. K., Cobb, B. S., Sexton, T., Fraser, P., Fisher, A. G., Merkenschlager, M. (2009). Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature 460, 410–413. Abstract

Mon, 14 Jun 2010

2010-06-14 14:15:11 GMT

Savarese, F., Dávila, A., Nechanitzky, R., De La Rosa-Velazquez, I., Pereira, C. F., Engelke, R., Takahashi, K., Jenuwein, T., Kohwi-Shigematsu, T., Fisher, A. G., Grosschedl, R. (2009). Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes & Development 23, 2625–2638. Abstract

Mon, 14 Jun 2010

2010-06-14 14:11:42 GMT

Raaijmakers, M. H., Mukherjee, S., Guo, S., Zhang, S., Kobayashi, T., Schoonmaker, J. A., Ebert, B. L., Al-Shahrour, F., Hasserjian, R. P., Scadden, E. O., Aung, Z., Matza, M., Merkenschlager, M., Lin, C., Rommens, J. M., Scadden, D. T. (2010). Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 464, 852–857. Abstract

Mon, 14 Jun 2010

2010-06-14 14:10:55 GMT

Landeira, D., Sauer, S., Poot, R., Dvorkina, M., Mazzarella, L., Jørgensen, H. F., Pereira, C. F., Leleu, M., Piccolo, F. M., Spivakov, M., Brookes, E., Pombo, A., Fisher, C., Skarnes, W. C., Snoek, T., Bezstarosti, K., Demmers, J., Klose, R. J., Casanova, M., Tavares, L., Brockdorff, N., Merkenschlager, M., Fisher, A. G. (2010). Jarid2 is a Prc2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of Prc1 and RNA polymerase II to developmental regulators. Nature Cell Biology 12, 618–624. Abstract

Tue, 8 Jun 2010

2010-06-08 10:50:49 GMT

Spivakov, M. & Fisher, A. G. (2007). Epigenetic signatures of stem-cell identity. Nature Reviews Genetics 8, 263-271. Abstract

Tue, 8 Jun 2010

2010-06-08 10:50:34 GMT

Pereira, C. F., Terranova, R., Ryan, N. K., Santos, J., Morris, K. J., Cui, W., Merkenschlager, M. & Fisher, A. G. (2008). Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. PLoS Genetics 4, e1000170. Abstract | Full text

Thu, 11 Feb 2010

2010-02-11 14:17:12 GMT

Santos, J., Pereira, C. F., Di Gregorio, A., Spruce, T., Alder, O., Rodriguez, T., Azuara, V., Merkenschlager, M., Fisher, A. (2010). Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo. Epigenetics & Chromatin 3 (1), 1+ Abstract

Mon, 2 Mar 2009

2009-03-02 17:30:10 GMT

Suárez, Y., Fernández-Hernando, C., Yu, J., Gerber, S. A., Harrison, K. D., Pober, J. S., Iruela-Arispe, M. L., Merkenschlager, M. & Sessa, W. C. (2008). Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proceedings of the National Academy of Sciences of the United States of America 105 (37), 14082–14087. Abstract

Mon, 2 Mar 2009

2009-03-02 17:28:48 GMT

Merkenschalger, M. & Wilson, C. B. (2008). RNAi and chromatin in T cell development and function. Current Opinion in Immunology 20 (2), 131–138. Abstract

Mon, 2 Mar 2009

2009-03-02 17:28:05 GMT

Rowell, E., Merkenschlager, M. & Wilson, C. B. (2008). Long-range regulation of cytokine gene expression. Current Opinion in Immunology 20 (3), 272–280. Abstract

Thu, 15 Jan 2009

2009-01-15 11:23:43 GMT

Azuara, V., Perry, P., Sauer, S., Spivakov, M., Jørgensen, H. F., John, R. M., Gouti, M., Casanova, M., Warnes, G., Merkenschlager, M. & Fisher, A. G. (2006). Chromatin signatures of pluripotent cell lines. Nature Cell Biology 8, 532-538. Abstract

Thu, 15 Jan 2009

2009-01-15 11:23:31 GMT

Thompson, E. C., Cobb, B. S., Sabbattini, P., Meixlsperger, S., Parelho, V., Liberg, D., Taylor, B., Dillon, N., Georgopoulos, K., Jumaa, H., Smale, S. T., Fisher, A. G. & Merkenschlager, M. (2007). Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity 26, 335-344. Abstract

Thu, 15 Jan 2009

2009-01-15 11:23:05 GMT

Parelho, V., Hadjur, S., Spivakov, M., Leleu, M., Sauer, S., Gregson, H. C., Jarmuz, A., Canzonetta, C., Webster, Z., Nesterova, T., Cobb, B. S., Yokomori, K., Dillon, N., Aragon, L., Fisher, A. G. & Merkenschlager, M. (2008). Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell 132, 422-433. Abstract

Sheardown, S., Norris, D., Fisher, A. & Brockdorff, N. (1996). The mouse Smxc gene exhibits developmental and tissue specific variation in degree of escape from X inactivation. Human Molecular Genetics 5, 1355-1360. Abstract | Full text

Merkenschlager, M. (1996). Tracing interactions of thymocytes with individual stromal cell partners. European Journal of Immunology 25, 892-896. Abstract

Merkenschlager, M., Graf, D., Lovatt, M., Bommhardt, U., Zamoyska, R. & Fisher, A. G. (1997). How may thymocytes audition for selection? Journal of Experimental Medicine 186, 1149-1158. Abstract | Full text

Graf, D., Fisher, A. G. & Merkenschlager, M. (1997). Rational primer design greatly improves differential display-PCR (DD-PCR). Nucleic Acids Research 25, 2239-2240. Abstract | Full text

Core, N., Bel, S., Gaunt, S. J., Aurrandion, M., Pearce, J., Fisher, A. & Djabali, M. (1997). Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 124, 721-729. Abstract | Full text

Brown, K. E., Guest, S. S., Smale, S. T., Hahm, K., Merkenschlager, M. & Fisher, A. G. (1997). Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91, 845-854. Abstract

Hahm, K., Cobb, B. S., McCarty, A. S., Brown, K. E., Klug, C. A., Lee, R., Akashi, K., Weissman, I. L., Fisher, A. G. & Smale, S. T. (1998). Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. Genes & Development 12, 782-796. Abstract | Full text

Merkenschlager, M., Power, O., Pircher, H. & Fisher, A. G. (1999). Intrathymic deletion of MHC class I-restricted CTL precursors by constitutive cross-processing of exogenous antigen. European Journal of Immunology 29, 1477-1486. Abstract

Ernst, P., Hahm, K., Cobb, B. S., Brown, K. E., Trinh, L. A., McCarty, A. S., Merkenschlager, M., Klug, C. A., Fisher, A. G. & Smale, S. T. (1999). Mechanisms of transcriptional regulation in lymphocyte progenitors: insight from an analysis of the terminal transferase promoter. Cold Spring Harbor Symposium on Quantitative Biology 64, 87-97.

Brown, K. E., Baxter, J., Graf, D., Merkenschlager, M. & Fisher, A. G. (1999). Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Molecular Cell 3, 207-217. Abstract

Aitman, T. J., Glazier, A. M., Wallace, C. A., Cooper, L. D., Norsworthy, P. J., Wahid, F. N., Al-Majali, K. M., Trembling, P. M., Mann, C. J., Shoulders, C. C., Graf, D., St. Lezin, E., Kurtz, T. W., Kren, V., Pravenec, M., Ibrahimi, A., Abumrad, N. A., Stanton, L. W. & Scott, J. (1999). Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nature Genetics 21, 76-83. Abstract

Lovatt, M., Yang, T.-H., Stauss, H., Fisher, A. G. & Merkenschlager, M. (2000). Different doses of agonistic ligand drive the maturation of functional CD4 and CD8 T cells from immature precursors. European Journal of Immunology 30, 371-381. Abstract

Hozumi, K., Ohtsuka, R., Suzuki, D., Ando, K., Ito, M., Nishimura, T., Merkenschlager, M. & Habu, S. (2000). Establishment of efficient reaggregation culture system for gene transfection into immature T cells by retroviral vectors. Immunology Letters 71, 61-66. Abstract

Cobb, B. S., Morales-Alcelay, S., Kleiger, G., Brown, K. E., Fisher, A. G. & Smale, S. T. (2000). Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding. Genes & Development 14, 2146-2160. Abstract | Full text

Barcenas-Morales, G., Merkenschlager, M., Wahid, F., Döffinger, R. & Ivanyi, J. (2000). Recessive expression of the H2A-controlled immune response phenotype depends critically on antigen dose. Immunology 99, 221-228. Abstract

Trinh, L. A., Ferrini, R., Cobb, B. S., Weinmann, A. S., Hahm, K., Ernst, P., Garraway, I. P., Merkenschlager, M. & Smale, S. T. (2001). Down-regulation of TDT transcription in CD4⁺CD8⁺ thymocytes by Ikaros proteins in direct competition with an Ets activator. Genes & Development 15, 1817-1832. Abstract | Full text

Smith, K., Seddon, B., Purbhoo, M. A., Zamoyska, R., Fisher, A. G. & Merkenschlager, M. (2001). Sensory adaptation in naive peripheral CD4 T cells. The Journal of Experimental Medicine 9, 1253-1261. Abstract

Skok, J. A., Brown, K. E., Azuara, V., Caparros, M.-L., Baxter, J., Takacs, K., Dillon, N., Gray, D., Perry, R. P., Merkenschlager, M. & Fisher, A. G. (2001). Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes. Nature Immunology 2, 848-854. Abstract

Graf, D., Timmons, P. M., Hitchins, M., Episkopou, V., Moore, G., Ito, T., Fujiyama, A., Fisher, A. G. & Merkenschalger, M. (2001). Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation. Mammalian Genome 12, 554-560. Abstract

Davodeau, F., Difilippantonio, M., Roldan, E., Malissen, M., Casanova, J.-L., Couedel, C., Morcet, J.-F., Merkenschalger, M., Nussenzweig, A., Bonneville, M. & Malissen, B. (2001). The tight interallelic positional coincidence that distinguishes T-cell receptor Jα usage does not result from homologous chromosomal pairing during VαJα rearrangement. The EMBO Journal 20, 4717-4729. Abstract

Brown, K. E., Amoils, S., Horn, J. M., Buckle, V. J., Higgs, D. R., Merkenschlager, M. & Fisher, A. G. (2001). Expression of α- and β-globin genes occurs within different nuclear domains in haemopoietic cells. Nature Cell Biology 3, 602-606. Abstract

Yang, T. H., Lovatt, M., Merkenschlager, M. & Stauss, H. J. (2002). Comparison of the frequency of peptide-specific cytotoxic T lymphocytes restricted by self- and allo-MHC following in vitro T cell priming. International Immunology 14, 1283-1290. Abstract | Full text

Smale, S. T. & Fisher, A. G. (2002). Chromatin structure and gene regulation in the immune system. Annual Review in Immunology 20, 427-462. Abstract

Kosak, S. T., Skok, J. A., Medina, K. L., Riblet, R., Le Beau, M. M., Fisher, A. G. & Singh, H. (2002). Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science 296, 158-162. Abstract

Graf, D., Nethisinghe, S., Palmer, D. B., Fisher, A. G. & Merkenschlager, M. (2002). The developmentally regulated expression of Twisted Gastrulation reveals a role for Bone Morphogenetic Proteins in the control of T cell development. The Journal of Experimental Medicine 196, 63-71. Abstract | Full text

Fisher, A. G. & Merkenschlager, M., (2002). Gene silencing, cell fate and nuclear organisation. Current Opinion in Genetics & Development 12, 193-197. Abstract

Fisher, A. G. (2002). Cellular identity and lineage choice. Nature Reviews Immunology 2, 977-982. Abstract

Baxter, J., Merkenschlager, M. & Fisher, A. G. (2002). Nuclear organisation and gene expression. Current Opinion in Cell Biology 14, 372-376. Abstract

Williams, R. R. E . & Fisher, A. G. (2003). Chromosomes, positions please! Nature Cell Biology 5, 388-390.

Liberg, D., Smale, S. T. & Merkenschlager, M. (2003) Upstream of Ikaros. Trends in Immunology 24, 567-570. Abstract

Bergman, Y., Fisher, A. & Cedar, H. (2003). Epigenetic mechanisms that regulate antigen receptor gene expression. Current Opinion in Immunology 15, 176-181. Abstract

Azuara, V. & Fisher, A. G. (2003). Maintaining transcriptional states through DNA replication. Cell Cycle 2, 521-524. Abstract

Azuara, V., Brown, K. E., Williams, R. R., Webb, N., Dillon, N., Festenstein, R., Buckle, V., Merkenschlager, M. & Fisher, A. G. (2003). Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication. Nature Cell Biology 5, 668-674. Abstract

Takács, K., Du Roure, C., Nabarro, S., Dillon, N., McVey, J. H., Webster, Z., MacNeil, A., Bartók, I., Higgins, C., Gray, D., Merkenschlager, M. & Fisher, A. G. (2004). The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes. Proceedings of the National Academy of Sciences of the United States of America 101, 16298-16303. Abstract

Su, R. C., Brown, K. E., Saaber, S., Fisher, A. G., Merkenschlager, M. & Smale, S. T. (2004). Dynamic assembly of silent chromatin during thymocyte maturation. Nature Genetics 36, 502-506. Abstract

Perry, P., Sauer, S., Billon, N., Richardson, W. D., Spivakov, M., Warnes, G., Livesey, F. J., Merkenschlager, M., Fisher, A. G. & Azuara, V. (2004). A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction. Cell Cycle 3, 1645-1650. Abstract

Merkenschlager, M., Amoils, S., Roldan, E., Rahemtulla, A., O'Connor, E., Fisher, A. G. & Brown, K. E. (2004). Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choice. The Journal of Experimental Medicine 200, 1437-1344. Abstract

Hewitt, S. L., High, F. A., Reiner, S. L., Fisher, A. G. & Merkenschlager, M. (2004). Nuclear repositioning marks the selective exclusion of lineage-inappropriate transcription factor loci during T helper cell differentiation. European Journal of Immunology 34, 3604-3613. Abstract

Baxter, J., Sauer, S., Peters, A., John, R., Williams, R., Caparros, M. L., Arney, K., Otte, A., Jenuwein, T., Merkenschlager, M. & Fisher, A. G. (2004). Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO Journal 23, 4462-4472. Abstract

Arney, K. L. & Fisher, A. G. (2004). Epigenetic aspects of differentiation. Journal of Cell Science 117, 4355-4363. Abstract | Full text

Terranova, R, Sauer, S., Merkenschlager, M. & Fisher, A. G. (2005). The reorganisation of constitutive heterochromatin in differentiating muscle requires HDAC activity. Experimental Cell Research 310, 344-356. Abstract

Parelho, V. & Merkenschlager, M. (2005). Gene expression: growing up together may help genes go their separate ways. European Journal of Human Genetics 13, 993-994. Abstract

Fisher, A. & Merkenschlager, M. (2005). Gene silencing in lymphocyte development. Seminars in Immunology 17, 103.

Cobb, B. S., Nesterova, T. B., Thompson, E., Hertweck, A., O'Connor, E., Godwin, J., Wilson, C. B., Brockdorff, N., Fisher, A. G., Smale, T. & Merkenschlager, M. (2005). T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. The Journal of Experimental Medicine 9, 1367-1373. Abstract | Full text

Wilson, C. B. & Merkenschlager, M. (2006). Chromatin structure and gene regulation in T cell development and function. Current Opinion in Immunology 18, 143-151. Abstract

Williams, R. R., Azuara, V., Perry, P., Sauer, S., Dvorkina, M., Jørgensen, H., Roix, J., McQueen, P., Misteli, T., Merkenschlager, M. & Fisher, A. G. (2006). Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus. Journal of Cell Science 119, 132-140. Abstract | Full text

Terranova, R., Pereira, C. F., Du Roure, C., Merkenschlager, M. & Fisher, A. G. (2006). Acquisition and extinction of gene expression programs are seperable events in heterokaryon programming. Journal of Cell Science 119, 2065-2072. Abstract | Full text

Jørgensen, H. F., Giadrossi, S., Casanova, M., Endoh, M., Koseki, H., Brockdorff, N. & Fisher, A. G. (2006). Polycomb repressive complexes restrain the expression of lineage-specific regulators in embryonic stem cells. Cell Cycle 5, 1411-1414. Abstract

Du Roure, C., Takács, K., Maxwell, P. H., Roberts, I., Dazzi, F., Cannella, L., Merkenschlager, M. & Fisher, A. G. (2006). Correction of severe anaemia using immuno-regulated gene therapy is achieved by restoring the early erythroblast compartment. British Journal of Haematology 132, 608-614. Abstract

Stock, J. K., Giardrossi, S., Casanova, M., Brookes, E., Vidal, M., Koseki, H., Brockdorff, N., Fisher, A. G. & Pombo, A. (2007). Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nature Cell Biology 9, 1428-1435. Abstract

Roessler, S., Györy, I., Imhof, S., Spivakov, M., Williams, R. R., Busslinger, M., Fisher, A. G. & Grosschedl, R. (2007). Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Molecular and Cellular Biology 27, 579-594. Abstract

Lande-Diner, L., Zhang, J., Ben-Porath, I., Amariglio, N., Keshet, I., Hecht, M., Azuara, V., Fisher, A. G., Rechavi, G. & Cedar, H. (2007). Role of DNA methylation in stable gene repression. The Journal of Biological Chemistry 282, 12194-12200. Abstract

Jørgensen, H. F., Azuara, V. , Amoils, S., Spivakov, M., Terry, A., Nesterova, T., Cobb, B. S., Ramsahoye, B., Merkenschlager, M. & Fisher, A. G. (2007). The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells. Genome Biology 8, R169. Abstract | Full text

Giadrossi, S., Dvorkina, M. & Fisher, A. G. (2007). Chromatin organization and differentiation in embryonic stem cell models. Current Opinion in Genetics & Development 17, 132-138. Abstract

Frye, M., Fisher, A. G. & Watt, F. M. (2007). Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. PLoS ONE 2, e763. Abstract | Full text

Shi, S., Yu, L., Chiu, C., Sun, Y., Chen, J., Khitrov, G., Merkenschlager, M., Holzman, L. B., Zhang, W., Mundel, P. & Bottinger, E. P. (2008). Podocyte-selective deletion of Dicer induces proteinuria and glomerulosclerosis. Journal of the American Society of Nephrology, (in the Press). Abstract

Sauer, S., Bruno, L., Hertweck, A., Finlay, D., Leleu, M., Spivakov, M., Knight, Z. A., Cobb, B. S., Cantrell, D., O'Connor, E., Shokat, K. M., Fisher, A. G. & Merkenschlager, M. (2008). T cell receptor signaling controls Foxp3 expression via P13K, Akt, and mTOR. Proceedings of the National Academy of Sciences of the United States of America 105, 7797-7802. Abstract

Nesterova, T. B., Popova, B. C., Cobb, B. S., Norton, S., Senner, C. E., Tang, Y. A., Spruce, T., Rodriguez, T. A., Sado, T., Merkenschlager, M. & Brockdorff, N. (2008). Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a. Epigenetics & Chromatin 1, 2. Abstract | Full text

Koralov, S. B., Muljo, S. A., Galler, G. R., Krek, A., Chakraborty, T., Kanellopoulou, C., Jensen, K., Cobb, B. S., Merkenschlager, M., Rajewsky, N. & Rajewsky, K. (2008). Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell 132, 860-874. Abstract | Full text

Kobayashi, T., Lu, J., Cobb, B. S., Rodda, S. J., McMahon, A. P., Schipani, E., Merkenschlager, M. & Kronenberg, H. M. (2008). Dicer-dependent pathways regulate chondrocyte differentiation and proliferation. Proceedings of the National Academy of Sciences of the United States of America 105, 1949-1954. Abstract

Gartenberg, M. R. & Merkenschlager, M. (2008). Condensin goes with the family but not with the flow. Genome Biology 9, 236. Abstract